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Discover Health Benefits Of Broccoli Sprouts

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Health Benefits of Broccoli Sprouts

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Broccoli Sprouts Causes Cancer Cells To Self Destruct.

Impact on developing or developed cancers

French researchers showed sulforaphane might do more than just activate antioxidants. Their research describes the ability of sulforaphane to cause cancer cells to self-destruct, known as apoptosis or programmed cell death. The multidimensional ability of sulforaphane both to eliminate or detoxify carcinogens and to kill cells with potential cancer-causing mutations suggests sulforaphane may have broader effects on developed cancer at various stages, as well as prevention.[30][31]

Scientists at the Amala Cancer Research Centre in India reported sulforaphane may inhibit the spread of B16F-10 melanoma cells in vitro. Mice were treated with sulforaphane either prior to, simultaneously, or following exposure to the carcinogens. Results indicated the simultaneous treatment of sulforaphane was most effective with a 95% reduction of lung tumor formation and a 94% increase in the life span of the animals. The findings suggest sulforaphane may have the ability to prevent metastasis of established cancers, rather than simply preventing development of cancers.[32]

Read More The Whole Section of Benefits Below

Summaries of some key studies:

Cancer

Carcinogen detoxification

An elevated level of hepatitis virus and environmental toxins results in a very high prevalence of liver cancer in a rural area of China. Scientists performed a clinical test to assess whether broccoli sprouts influenced the body’s abilities to detoxify carcinogens. In a single-blind, placebo-controlled trial, 100 test and 100 control subjects drank a water extract of three-day-old broccoli sprouts or a placebo daily over a period of two weeks. The broccoli sprouts group showed a significant decrease in aflatoxin-DNA adduct (a biomarker of DNA damage) levels with increasing levels of broccoli sprout consumption. The change in these biomarkers signals an enhanced detoxification (neutralization) of carcinogens from the human body, leading to a reduction in cancer risk.[9]

Tumor progression and activity

For the inhibition of breast cancer tumors, scientists reported sulforaphane and phenethyl isothiocyanate (PEITC) could prevent initial benign tumors in the lungs of mice produced by a cigarette carcinogen from developing into malignant cancer tumors. Using a model in which the animals were exposed to the carcinogens, scientists demonstrated sulforaphane inhibits the progression of the disease by causing the programmed death of the damaged cells. These findings suggest chemoprotective agents might be useful among people exposed to tobacco carcinogens, including current smokers, exsmokers or those exposed to second-hand smoke.[10]

Stomach cancer

Infection with the bacterium H. pylori can cause stomach ulcers and markedly increases the risk of developing stomach cancer. In vitro and animal experiments showed potent and selective antibacterial properties of sulforaphane and sulforaphane’s ability to selectively target the H. pylori bacteria, which are often difficult to eradicate. Also, sulforaphane was effective against H. pylori strains that had developed resistance to the typical antibiotic treatment. In a Japanese study involving patients infected with H. pylori bacteria, patients eating 100 grams (approximately 3.5 ounces) of broccoli sprouts daily for two months experienced substantially reduced measures of H. pylori infection when compared with control subjects fed a vegetable with no glucoraphanin. These results suggest sulforaphane from myrosinase-active broccoli sprouts may be responsible for the reduction of the bacteria, and a diet rich in myrosinase-active broccoli sprouts may be useful in reduction of H. pylori infection and chemoprevention against gastric cancer.[11][12]

Skin tumors

Some skin tumors form after exposure to UV radiation. Mice were exposed to damaging levels of UV light for 20 weeks in a study conducted at Johns Hopkins Medical School. Following the exposure, application of sulforaphane resulted in a 50% reduction in the number of mice with tumors. The number of tumors per mouse and the mass of tumors were also reduced. A significant aspect of the study is that administration of the chemoprotective agent was after carcinogen exposure, suggesting an ability to prevent the progression of cancer after cells are already damaged.[13][14][15][16]

Breast cancer

Work from Johns Hopkins, published in 1994, demonstrated chemoprotective effects of sulforaphane, showing its ability to reduce mammary tumor formation in rats. Scientists at Shanghai Cancer Center in China conducted a retrospective (epidemiological) study of 350 pairs of women. One of each pair had breast cancer. The other was cancer-free. The study results revealed the women who had eaten higher levels of Brassica vegetables—broccoli, cabbage, cauliflower and kale—all of which contain glucoraphanin and related compounds—were 50% less likely to be diagnosed with breast cancer. Cornblatt and colleagues (2007) have now shown that sulforaphane actually reaches breast tissue in humans within an hour or so of consumption.[17][18][19]

Prostate cancer

Human prostate cancer cells responded to treatment with sulforaphane in the form of broccoli sprout extracts, showing dramatic increases in their Phase 2 protective enzymes. Dr. James D. Brooks, Urology Department, Stanford University, suggests broccoli sprouts, a rich natural source of sulforaphane, might be appropriate for use in intervention trials in humans.[20][21][22]

Colon cancer

American Health Foundation researchers showed sulforaphane significantly inhibited the formation of colon cancer in rats. Much work has demonstrated the ability of sulforaphane and broccoli sprouts extracts to inhibit cancer in vitro in human colon cancer cells.[23][24][25]

Bladder cancer

Epidemiological evidence strongly suggested a role for cruciferous vegetables in prevention of bladder cancer. Indeed, although an analysis of 47,909 men in the Health Professionals Follow-Up Study showed virtually no correlation between cancer reduction and high consumption of fruits and vegetables overall, or yellow or green leafy vegetables specifically, it did show a statistically significant reduction among those men who consumed large amounts of cruciferous vegetables.

Several studies have suggested the bladder is one of the most responsive organs to induction of detoxification enzymes by extract, and demonstrated this was evident in human bladder cancer cells in vitro and using broccoli sprouts rich in sulforaphane potential in animal models in vivo. In addition, studies have also shown sulforaphane and broccoli sprout extract can induce apoptosis and cell cycle arrest in human bladder cancer cells in vitro, while showing the activity levels from pure sulforaphane and broccoli sprout extracts were virtually equivalent, and confirming this effect is due exclusively to the sulforaphane potential in the sprouts, not other components.[26][27][28][29]

Impact on developing or developed cancers (Excerpt Taken And Mentioned at Start of Blog Post as A Highlight)

French researchers showed sulforaphane might do more than just activate antioxidants. Their research describes the ability of sulforaphane to cause cancer cells to self-destruct, known as apoptosis or programmed cell death. The multidimensional ability of sulforaphane both to eliminate or detoxify carcinogens and to kill cells with potential cancer-causing mutations suggests sulforaphane may have broader effects on developed cancer at various stages, as well as prevention.[30][31]

Scientists at the Amala Cancer Research Centre in India reported sulforaphane may inhibit the spread of B16F-10 melanoma cells in vitro. Mice were treated with sulforaphane either prior to, simultaneously, or following exposure to the carcinogens. Results indicated the simultaneous treatment of sulforaphane was most effective with a 95% reduction of lung tumor formation and a 94% increase in the life span of the animals. The findings suggest sulforaphane may have the ability to prevent metastasis of established cancers, rather than simply preventing development of cancers.[32]

Other health conditions

Cholesterol levels

In a pilot study, researchers at Tokyo University of Agriculture and Technology and the Japan Institute for the Control of Aging found that individuals who ate 100 grams of broccoli sprouts a day for just one week showed decreased overall levels of cholesterol, while increasing HDL or good cholesterol. The glucoraphanin in broccoli sprouts also appears to reduce the amount of oxidative stress or cell destruction caused by free radicals.[33]

High blood pressure

In laboratory studies with animals bred to have high blood pressure and are therefore at high risk for stroke, Dr. Bernhard Juurlink at the University of Saskatchewan in Saskatoon, Canada, found sulforaphane-induced Phase 2 enzymes from broccoli sprouts improved cardiovascular health by decreasing inflammation and improving heart, artery and kidney function.[34]

Macular degeneration

Johns Hopkins University scientists studied the ability of sulforaphane to protect retinal pigment epithelial cells from damage by chemical carcinogens and by ultraviolet light. These processes are the similar to the kind of damage that can lead to macular degeneration in the eye. Macular degeneration is the leading cause of blindness among the elderly.[35][36][37]

COPD

Researchers in the Department of Environmental Health Sciences and the Division of Pulmonary and Critical Care Medicine at Johns Hopkins School of Medicine reported sulforaphane increases the activity of the phase II enzyme gene Nrf2 in human lung cells, which protects cells from damage caused by toxins. Thus, presenting the possibility of therapy directed toward enhancing Nrf2-regulated antioxidants, reducing the effects of oxidative stress in COPD.[38]

Diabetes

Sulforaphane activates the Nrf2 protein, which protects cells and tissues from damage by stimulating the phase 2 enzymes, which detoxify ROS molecules. Sulforaphane reduced reactive oxygen species (ROS) molecules by 74%, thus reducing damage to blood vessel cells by hyperglycemia. High glucose levels can cause a threefold increase in ROS levels, which can damage human cells. These results suggest sulforaphane from broccoli may help reverse the damaging effects of diabetes-linked vascular disease.[39]

A collaborative group in Iran showed a myrosinase-active broccoli sprout powder had favorable effects on oxidative stress status in type 2 diabetes patients over a four-week period. The study used doses of 5 or 10 grams daily, delivering 112 and 225 micromoles sulforaphane, respectively. Positive effects were seen at both doses, although effects on lipid peroxidation were only seen at the higher dose.[40]

Changes Made:  (Excerpt Taken And Mentioned at Start of Blog Post as A Highlight) added to inform reader that  Impact on developing or developed cancers Section is used at start of Blog Post as A highlight
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Check Out Article That Describes Benefits and How To Cook Broccoli.

Broccoli is a vegetable that has many benefits. It is rich in nutrients, fiber, provitamin A, carotenoids, vitamin E, folic acid, and vitamin C. Broccoli is a vegetable with a low calorie, low fat and saturated fat content-free, high potassium and low in sodium and also it does not contain cholesterol.

Broccoli is even considered as one of the vegetables that can prevent and overcome breast cancer. This has been proven through various studies about the benefits of broccoli. Chemical compounds found in vegetables are targeting the cells that become factors for tumor growth. Cancer stem cells can be killed because broccoli has a high content sulforaphane. Sulforaphane also prevent the development or spread of disease.

Moreover, broccoli is useful to solve all the problems of the stomach, such as constipation. Fiber in broccoli may help prevent constipation. The latest research and more specifically provides an illustration that this vegetable can reduce the risk of a variety of digestive disorders such as gastritis, gastric infections and possibly stomach cancer.

Sulforaphane in broccoli are also known to increase the production of phase II enzymes in the liver. This enzyme plays took carcinogenic substances produced from the compound procarcinogen and out of cells. Keep in mind, broccoli that has been boiled too long has lower the content of sulforaphane than in fresh broccoli sprouts.

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